Ignacio García-Casas, Antonio Montes, Diego Valor, Clara Pereyra and Enrique J. Martínez de  la Ossa Foamed polycaprolactone impregnated with quercetin was carried out with batch foaming technique using supercritical CO2. Experimental design was developed to study the influence of pressure (15-30 MPa), temperature (308-333 K) and depressurization rate (0.1-20) on the foam structure, melting temperature […]

Diego Valor, Antonio Montes , Marilia Monteiro , Ignacio García-Casas, Clara Pereyra  and Enrique Martínez de la Ossa Poly(D,L,-lactide-co-glycolide) (PLGA) foam samples impregnated with rutin were successfully produced by supercritical foaming processes. A number of parameters such as pressure (80–200 bar), temperature (35–55 C), depressurization rate (5–100 bar/min), ratio lactide:glycolide of the poly(D,L,-lactide-co-glycolide) (50:50 and […]

Antonio Montes , Diego Valor , Laura Delgado, Clara Pereyra and Enrique Martínez de la Ossa Conjugated polymers are biomaterials with high conductivity characteristics because of their molecular composition. However, they are too rigid and brittle for medical applications and therefore need to be combined with non-conductive polymers to overcome or lessen these drawbacks. This […]

Diego Valor , Antonio Montes , Antonio Cózar, Clara Pereyra and Enrique Martínez de la Ossa Scaffolds are advanced devices employed in tissue engineering, as they are intended to mimic the characteristics of extracellular matrices. In this respect, conjugated materials are gaining relevance in the manufacturing of the foams used for therapeutic scaffolds, since they […]

Pilar Grosso, Cristina Cejudo,, Ismael Sánchez-Gomar, Mª Carmen Durán-Ruiz, Rafael Moreno-Luna, Lourdes Casas, Clara Pereyra and Casimiro Mantell The addition of natural substances with pharmacoactive properties to polymeric biomedical devices would provide beneficial regarding the assimilation of these endoprostheses when implanted into a patient’s body. The added drug would facilitate endothelization by regulating the inflammatory […]

 Cristina Cejudo-Bastante , Lidia Verano-Naranjo , Noemí  Toro-Barrios, Clara Pereyra , Casimiro Mantell and Lourdes Casas Identifying new polymers from natural resources that can be effectively functionalized can have a substantial impact on biomedical devices and food preservation fields. Some of these polymers would be made of biodegradable, renewable and compostable materials, and present the kind […]

 José María Rosales, Cristina Cejudo, Lidia Verano, Lourdes Casas, Casimiro Mantell and Enrique José Martínez de la Ossa Polylactic Acid (PLA) filaments impregnated with ethanolic mango leaves extract (MLE) with pharmacological properties were obtained by supercritical impregnation. The effects of pressure, temperature and amount of extract on the response variables, i.e., swelling, extract loading and bioactivity of the PLA […]

Lidia Verano Naranjo , Cristina Cejudo Bastante, Lourdes Casas Cardoso , Casimiro Mantell Serrano and Enrique José  Martínez de la Ossa Fernández Ketoprofen (KET) is an anti-inflammatory drug often used in medicine due to its analgesic and antipyretic effects. If it is administered in a controlled form by means of different dosing devices, it acts throughout the patient’s […]